Researchers Focus on Risk Factors for Leukemia After Breast Cancer Treatment

leukemia text and pills

HealthDay News

MONDAY, Dec. 7, 2015 (HealthDay News) -- Researchers say they're zeroing in on factors that may increase the risk of leukemia after breast cancer treatment.

The findings are a step forward in determining ways to prevent this complication in breast cancer survivors. While the breast cancer treatments target malignant cells, they can also affect healthy cells and could increase the risk of leukemia later, the researchers said.

The scientists looked at 88 breast cancer survivors with treatment-related leukemia and found that many had a personal and family history of cancer, suggesting a genetic susceptibility to cancer.

Also, 20 percent of the women had an inherited gene mutation that increases the risk of breast cancer, according to the study published Dec. 7 in the journal Cancer.

"The findings justify a long-term, follow-up study of women with and without inherited breast cancer gene mutations who are treated with similar therapy for breast cancer," said study leader Dr. Jane Churpek, from the University of Chicago.

"This would enable us to understand how these genes impact therapy-related leukemia risk, and whether specific treatments come with higher risks based on a woman's inherited genetics," Churpek said in a journal news release.

Doctors could then have patient-specific conversations about the possible risks and benefits of chemotherapy and radiation treatments for breast cancer, she added.

It can be difficult to determine whether leukemia in breast cancer survivors is or is not treatment-related, Dr. Judith Karp and Dr. Antonio Wolff, from Johns Hopkins University School of Medicine in Baltimore, noted in an accompanying journal editorial.

"Existing familial cancer registries that are prospectively following breast cancer patients and their families are uniquely positioned to ascertain the true frequency of subsequent leukemias and their associations with the therapies received," they wrote.

SOURCE: Cancer, news release, Dec. 7, 2015

Copyright © 2015 HealthDay. All rights reserved.


Anxious About Going out into the World? You’re Not Alone, but There’s Help

Deciding which of your normal activities you wish to resume and which to let go of helps you to prepare for the future

Your Health

At What Age Are People Usually Happiest? New Research Offers Surprising Clues

In an ongoing study, most of those interviewed seemed to recognize that they were happier in their 30s than they were in their 20s — but there are caveats

Science and Technology

How Inequity Gets Built Into America’s Vaccination System

People eligible for the coronavirus vaccine are running up against barriers that are designed into the very systems meant to serve those most at risk of dying of the disease.

Prevention & Screenings