Professor of Medicine
University of Connecticut Health Center
Scleroderma is a chronic, autoimmune disease that most often strikes women during middle age. It can cause hardening and thickening of the skin and attack the heart, lungs, kidneys and gastrointestinal tract.
The disease is caused by inflammation of small veins and arteries leading to overproduction of collagen in your connective tissue. Collagen is normally responsible for keeping your skin and organs supple, but when it is overproduced, it makes tissue thick and immobile.
Scleroderma literally means "hard skin," but the disease is most serious when it affects internal organs, hardening the tissues of the lungs, heart, kidneys, intestinal tract, muscles and joints. This stiffening can seriously harm the circulatory, digestive and respiratory systems. In some organs, the inflammation of blood vessels causes blockage of blood to the areas.
What causes scleroderma?
How is scleroderma diagnosed?
How is scleroderma treated?
What special precautions do I need to take if I have scleroderma and want to have a baby?
How can I prevent scleroderma?