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Health Topics A-ZText size: A A A July 6, 2008

Diagnosis

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Metabolic syndrome is a very complicated condition to diagnose. The only visible symptom of metabolic syndrome is being overweight, but that is no guarantee that you'll have the condition. And you can have metabolic syndrome even if you aren't overweight.

There are at least six definitions for metabolic syndrome. The primary one used in the U.S. comes from the National Heart, Lung, and Blood Institute (NHLBI). The chart below shows the differences among the definitions.










Component World Health Organization European
Group for the Study of
Insulin Resistance
ATP III (National Institutes
of Health)
American Association of Clinical Endocrin-
ologists
Inter-
national Diabetes Federation
American Heart Association/
National Heart, Lung, and Blood Institute
Obesity Waist/height ratio more than 0.85 in women, 0.90 in men; BMI of 30 or higher Waist circum-
ference more than 31.5 inches in women
Waist circum-
ference more than 88 cm in women, 102 cm in men
BMI of 25 or higher Waist circum-
ference depending on ethnicity
Waist circumference more than 34 inches in women, 40 inches in men
Triglycerides or taking medication for high triglycerides 150 mg/dL or higher 150 mg/dL or higher 150 mg/dL or higher 150 mg/dL or higher 150 mg/dL or higher 150 mg/dL or higher
HDL
Women

Men

39 mg/dL or less

35 mg/dL or less

39 mg/dL or less

39 mg/dL or less

50 mg/dL or less

40 mg/dL or less

50 mg/dL or less

40 mg/dL or less

50 mg/dL or less

40 mg/dL or less

50 mg/dL or less

40 mg/dL or less

Blood pressure 140/90 or higher 140/90 or higher 130/85 or higher 130/85 or higher 130/85 or higher 130/85 or higher
Marker of insulin sensitivity Low insulin sensitivity Hyper-
insulinemia
---- ---- ---- ----
Fasting blood glucose More than 110 mg/dL or type 2 diabetes More than 110 mg/dL More than 110 mg/dL or type 2 diabetes More than 110 mg/dL 110 mg/dL or higher, or type 2 diabetes 110 mg/dL or higher, or type 2 diabetes

The WHO, for instance, requires evidence of insulin resistance or diabetes to make a diagnosis of metabolic syndrome, while the IDF requires a certain degree of abdominal obesity. The NHLBI, however, considers the five components equal in importance. The WHO's definition is designed to identify people at greater risk for diabetes; while the NHLBI's definition is designed to identify those with greater risk for cardiovascular disease (CVD).

In the U.S., however, there's general agreement among medical professionals to use the NHLBI definition, in part because it's so difficult to test individuals for insulin resistance in the typical health care provider's office.

The reality, however, is that any one of the five risk factors increases your risk of cardiovascular disease whether you have metabolic syndrome or not. So whether you have one or all five of the components, you and your health care professional need to work together to reduce that risk and any others you may have.

To diagnose metabolic syndrome, your health care professional should measure the five components involved in the condition: blood pressure, blood triglyceride level, HDL cholesterol level, waist circumference and fasting blood glucose level. You will need to fast for at least 12 hours before the blood tests.

If you have polycystic ovarian syndrome, or PCOS, you should ask your health care professional to evaluate you for metabolic syndrome. This condition affects 10 to 20 percent of U.S. women of childbearing age. Typical symptoms include irregular or absent menstruation, obesity and hair on the face and other parts of the body where women typically don't have much hair, a condition called hirsutism. Women with PCOS also often have high levels of testosterone and often have trouble getting pregnant.

Some research finds that women with PCOS are 11 times more likely to have metabolic syndrome. What we don't know is whether the components of metabolic syndrome cause the PCOS or vice versa. But women with PCOS tend to be overweight, have insulin resistance, have high levels of fasting blood glucose and, in fact, a much higher risk overall of cardiovascular disease and diabetes.

 
View References for this Health Topic Create Date: 11/14/06
Date Last Updated: 11/14/06
Review Date: 11/14/06
 
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